منابع مشابه
Cytokine signaling: Inhibitors keep cytokines in check
Most mammalian cell types express a wide variety of cytokine receptors at the cell surface. These receptors translate and transduce various signals from the external environment to the interior of the cell to generate the appropriate response. The last five years have been a period of remarkable progress in elucidating the biochemistry of cytokine signaling. The discovery and characterization o...
متن کاملA plan to keep carbon in check.
Retreating glaciers, stronger hurricanes, hotter summers, thinner polar bears: the ominous harbingers of global warming are driving companies and governments to work toward an unprecedented change in the historical pattern of fossil-fuel use. Faster and faster, year after year for two centuries, human beings have been transferring carbon to the atmosphere from below the surface of the earth. To...
متن کاملCan microRNAs keep inflammasomes in check?
Inflammasomes are multi-protein signaling platforms that are primed upon sensing pathogen-associated molecular patterns (PAMPs) as well as endogenous damage-associated molecular patterns (Kolliputi et al., 2010, 2012). Once primed, a complex forms between the inflammasome sensor, an adaptor protein with a caspase recruiter domain (ASC), and caspase-1, which leads to the cleavage of pro-inflamma...
متن کاملHolding the inflammatory system in check: NLRs keep it cool
Inflammation is a double-edged sword. While short-lived, acute inflammation is essential for the repair and resolution of infection and damage, uncontrolled and unresolved chronic inflammation is central to several diseases, including cancer, autoimmune diseases, allergy, metabolic disease, and cardiovascular disease. This report aims to review the literature regarding several members of the nu...
متن کاملHeparan sulfotransferases Hs6st1 and Hs2st keep Erk in check for mouse corpus callosum development.
The corpus callosum (CC) connects the left and right cerebral hemispheres in mammals and its development requires intercellular communication at the telencephalic midline mediated by signaling proteins. Heparan sulfate (HS) is a sulfated polysaccharide that decorates cell surface and extracellular matrix proteins and regulates the biological activity of numerous signaling proteins via sugar-pro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature
سال: 2012
ISSN: 0028-0836,1476-4687
DOI: 10.1038/483158b